Methods For Identifying Compounds Effective To Inc

专利名称：Methods For Identifying Compounds

Effective To Increase The Expression OrActivity Of Aspartyl Aminopeptidase InMammalian Pancreatic Islet Cells, AndMethods For Decreasing Angiotensin IILevels In Mammalian Pancreatic Islet Cells

发明人：Yuanxiu Chen申请号：US13240837申请日：20110922

公开号：US201200714A1公开日：20120322

摘要：The methods provided herein are based on the discovery, as described in moredetail herein, that aspartyl aminopeptidase (DAP) is expressed in mammalian pancreaticislet cells and that increased DAP expression results in decreased angiotensin II (Ang II)levels in the islet cells. Methods are provided for identifying compounds effective toincrease the expression and/or activity of DAP in mammalian pancreatic islet cells andthereby are effective to decrease Ang II levels in the islet cells. Methods are alsoprovided for decreasing Ang II levels in a subject having Ang II induced pancreas islet celldysfunction and/or suffering or susceptible to type 1 diabetes, as well as for thetreatment or prevention of type 1 diabetes comprising administering to the subject atherapeutically effective amount of the compound identified according to the methodsherein.

申请人：Yuanxiu Chen

地址：Potomac MD US

国籍：US

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