1,4-benzothiazepine derivatives

专利名称：1,4-benzothiazepine derivatives

发明人：Noboru Kaneko,Tatsushi Oosawa,Teruyuki

Sakai,Hideo Oota

申请号：US08/0812申请日：19930625公开号：US016066A公开日：19950516

摘要：An object of the invention is to provide compounds having a myocardial KD(Kinetic cell death)-inhibiting effect without being accompanied by a cardiodepressanteffect.

A 1,4- benzothiazepine derivative represented by the following Formula [I]: ##STR1##wherein each of substituent groups is defined as follows: R represents H or a C. sub.1 -C.sub.3 lower alkoxy group; X represents O or H.sub.2 ; n represents 1 or 2; R.sup.1represents H, a substituted phenyl group wherein the substituent group is OH or aC.sub.1 -C.sub.3 lower alkoxy group, ##STR2## a C.sub.1 -C.sub.3 lower alkoxy group,##STR3## wherein R. sup.2 represents a C.sub.1 -C.sub.3 acyl group, and ph represents aphenyl group, or a pharmaceutically acceptable salt thereof.

申请人：KIRIN BREWERY CO., LTD.

代理机构：Scully, Scott, Murphy & Presser

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