1,5-benzothiazepine derivatives, their preparation

专利名称：1,5-benzothiazepine derivatives, their

preparation and their use in the treatmentof cardiovascular disorders

发明人：Yanagisawa, Hiroaki c/o Sankyo Company

Limited,Fujimoto, Koichi c/o Sankyo

Company Limited,Shimoji, Yasuo c/o SankyoCompany Limited,Kanazaki, Takuro c/oSankyo Company Limited,Koike, Hiroyuki c/oSankyo Company Limited,Nishino, Hiroshi c/oSankyo Company Limited

申请号：EP3075.8申请日：190725公开号：EP0353032B1公开日：19920226

摘要：Compounds of formula (I): [in which: R¹ is aryl or aromatic heterocyclic; R² and R³are hydrogen, alkyl, alkoxy, halogen, phenyl, phenoxy, C₁ - C₆ alkylthio, phenylthio, C₁ - C₆haloalkyl, cyano or nitro, or together are alkylene optionally containing oxygen; R⁴ ishydrogen, aliphatic acyl, cycloalkylcarbonyl, cycloalkoxycarbonyl, aromatic acyl,alkoxycarbonyl or benzyloxycarbonyl; R⁵ and R⁶ are alkyl; and X is oxygen, sulphur ormethylene] have calcium channel blocking activity and can serve for the treatment orprophylaxis of cardiovascular diseases and disorders. They may be prepared by reacting acorresponding compound where R⁴ is hydrogen and the aminoethyl group is replaced byhydrogen with a compound providing the aminoethyl group and then, if required,

acylating the product.

申请人：SANKYO COMPANY LIMITED

地址：5-1 NIHONBASHI HONCHO 3-CHOME CHUO-KU; TOKYO

代理机构：Gibson, Christian John Robert

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