Materials and methods for preventing and treating

专利名称：Materials and methods for preventing and

treating microbe-mediated epithelialdisorders

发明人：John C. Alverdy申请号：US14936088申请日：20151109公开号：US099946B2公开日：20170124

摘要：The present invention provides pharmaceutical compositions in the form ofrelatively high molecular weight biocompatible polymers such as polyethylene glycol,optionally supplemented with a protective polymer such as dextran and/or essentialpathogen nutrients such as L-glutamine. Also provided are methods for preventing ortreating gut-derived sepsis attributable to intestinal pathogens such as by administeringhigh molecular weight polyethylene glycol as well as methods for monitoring theadministration of high molecular weight polyethylene glycol, such as in methods ofpreventing, ameliorating or treating microbe-induced epithelial disorders, as exemplifiedby gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammalsrecovering from surgical intervention or suffering from a disease or disorder, providingindications of suitable animals to receive preventative treatment. Finally, the inventionprovides a composition comprising infant formula and polyethylene glycol and methodsfor using that composition.

申请人：THE UNIVERSITY OF CHICAGO

地址：Chicago IL US

国籍：US

代理机构：Marshall, Gerstein & Borun LLP

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