COMPOSITIONS FOR PRESERVING INSULIN-PRODUCING CELL

专利名称：COMPOSITIONS FOR PRESERVING INSULIN-PRODUCING CELLS AND INSULINPRODUCTION AND TREATING DIABETES

发明人：Jack J. Hawiger,Daniel J. Moore,Ruth Ann

Veach,Jozef Zienkiewicz

申请号：US15181059申请日：20160613

公开号：US201603431A1公开日：20161208

摘要：Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo isletprotection following a 2-day course of intense treatment in autoimmune diabetes-prone,non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), whichresulted in a diabetes-free state for one year without apparent toxicity and the need touse insulin. cSN50 precipitously reduces the accumulation of islet-destructiveautoreactive lymphocytes while enhancing activation-induced cell death of T and Blymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine andchemokine production in immune cells in this model of human T1D. cSN50 also providescytoprotection of beta cells, therefore preserving residual insulin-producing capacity.Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 andcSN50.1 can result in lowering of fasting blood glucose levels and may ameliorate (e.g.,reduce, eliminate) insulin resistance, the compositions, methods and cells describedherein can also be used for treating Type 2 diabetes (T2D).

申请人：VANDERBILT UNIVERSITY

地址：Nashville TN US

国籍：US

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